Yes. Active Hydration Serum is safe for use with REDEFINE AMP MD and REDEFINE Night Renewing Serum. In fact, Active Hydration Serum helps prime skin and can amplify the effects of product layered on top of it. When used together you are able to maximize the anti-aging benefits of your Regimen. To incorporate with AMP MD Derma-Roller and Night Renewing Serum use the following steps: 1) Cleanse and tone skin; 2) Roll with AMP MD Derma-Roller; 3) Layer Active Hydration Serum; 4) Apply Night Renewing Serum; and 5) Continue with Step 3 or the remaining products in your routine.