Yes. Active Hydration Serum is safe for use with REDEFINE AMP MD. In fact, Active Hydration Serum helps prime skin and can amplify the effects of product layered on top of it. When used together you are able to maximize the anti-aging benefits of your Regimen. To incorporate Active Hydration Serum with the AMP MD Derma-Roller in your nightly routine use the following steps: 1) Cleanse and tone skin; 2) Roll with AMP MD Derma-Roller; 3) Layer Active Hydration Serum; and 4) Continue with Step 3 or the remaining products in your routine.