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Niacinamide for Smoothing Fine Lines


Niacinamide for Smoothing Fine Lines

Fine lines are a natural sign of aging skin, and niacinamide, a clinically tested form of vitamin B3, is a demonstrated ingredient to support smoother, firmer-looking skin. Recommended by dermatologists, niacinamide supports the skin’s barrier and enhances elasticity, making it a powerful addition to any skincare regimen backed by real results.

Discover dermatologist-developed solutions. Shop clinically tested niacinamide products and target fine lines with visible, proven results.

What Is Niacinamide?


Niacinamide, also known as nicotinamide, is a water-soluble vitamin B3 derivative that the skin readily absorbs. It delivers gentle yet effective support, suitable even for sensitive skin types. Found in serums and moisturizers, niacinamide operates with clinically tested efficacy to improve the appearance of the skin, with minimal risk of irritation.

How Niacinamide Smooths Fine Lines

Scientific studies show niacinamide optimizes collagen, a vital protein that maintains skin firmness and elasticity. As collagen naturally declines with age, wrinkles and sagging appear. Niacinamide works to:

  • Plump skin and diminish the look of fine lines
  • Enhance elasticity for a firmer, more resilient appearance
  • Strengthen the skin’s moisture barrier to address dryness that can emphasize lines

Additionally, its antioxidant properties help defend against environmental aggressors, supporting smoother skin over time.

Additional Benefits of Niacinamide

Beyond targeting visible fine lines, niacinamide offers multiple clinically tested benefits:

  • Regulates excess oil production, reducing the look of pores and refining skin texture
  • Minimizes the risk for redness and inflammation
  • Brightens uneven skin tones for a radiant complexion 
  • Supports hydration by locking in moisture and supporting  the skin barrier

Incorporating Niacinamide in Your Routine


Niacinamide pairs well with other dermatologist-recommended ingredients like hyaluronic acid and peptides. It rarely causes irritation and suits all skin types, making it a safe, effective choice in daily skincare. For best results:

  • Use a serum or moisturizer with 2% to 10% niacinamide consistently
  • Apply after cleansing and before heavier creams or sunscreen
  • Expect visible improvements in skin texture and fine lines within 4 to 12 weeks
  • Always complement your regimen with broad-spectrum SPF to protect against UV damage

This dermatologist-recommended ingredient supports long-term healthy-looking skin, delivering clinically backed efficacy and consistent results over time.

Rodan + Fields – Best Niacinamide for Smoothing Fine Lines Products

REVERSE Brightening Defense Lotion Broad Spectrum SPF 50 Mineral Sunscreen

Meet your skin’s daily defense: a multi-tasking, moisturizing mineral sunscreen that shields, brightens, and protects.

Formulated with Vitamin C and Niacinamide, it helps fade the appearance of dark spots, even out tone, and protect against UV damage, all while leaving skin hydrated and radiant.

Recommended Use: Daily, AM

Size: 30 mL / 1 Fl. Oz. U.S.

Product Details

What it is:

A luxurious, lightweight mineral sunscreen that does more than protect, it perfects.
This daily SPF helps fade the look of discoloration and dark spots, while infusing skin with brightening and antioxidant-rich ingredients for lasting radiance.

Why you need it:

Sun exposure, pollution, and environmental stressors can all trigger hyperpigmentation and uneven tone.

Our formula, enriched with SPF, Vitamin C, and Niacinamide, works to combat free radicals, minimize the look of dark marks, and maintain a smooth, luminous complexion, your ultimate partner in daily skin defense.

Backed by Science, Perfected by Experts

As the #1 Female Dermatologist-Founded Skincare Brand, our commitment to innovation never stops.


After more than two years of scientific refinement, we proudly present the New + Reformulated REVERSE Regimen featuring more key ingredients, consistent results, and a renewed mission:


Brighter skin, down to a science.

For best results, pair with the full REVERSE Regimen.

Item Number: RVSS050

Key Concerns

  • Look of Dark Spots
  • Dullness
  • Helps fade the appearance of Discoloration
  • Uneven Tone + Texture

Skin Type: Suitable for all skin types

Key Benefits

✔ Brightens and evens skin tone
✔ Helps fade the look of discoloration
✔ Moisturizes while shielding against UV damage
✔ Visibly reduces dullness for a healthy glow

Powered by Proven Ingredients

Mineral Sunscreen Actives

Naturally protect against UVA + UVB rays that cause visible signs of premature aging and pigmentation.

Vitamin C + Niacinamide

Brighten, balance, and reduce visible dark spots for a refreshed, even complexion.

Shea Butter

Deeply hydrates and softens skin throughout the day.

How to Use

When: Every morning (A.M.)

  1. After cleansing and toning, apply an even layer over the face and neck.
  2. Avoid the eye area.
  3. Reapply every 2–3 hours when exposed to the sun or after swimming, sweating, or towel-drying.

REDEFINE Overnight Reparative Lotion

Wake up to visibly smoother, firmer, and more youthful-looking skin. This lightweight nighttime lotion deeply hydrates while improving the look of fine lines, deep wrinkles, and loss of firmness, all while you rest.

Recommended Use: Once daily, PM (after toner) Size: 30 mL / 1.0 Fl. Oz. U.S.

Product Details

What it is: A fast-absorbing night lotion that works while you sleep to balance moisture, refine tone and texture, and visibly lift and firm the skin. If you prefer a richer texture, explore our alternative night cream option to customize your Redefine Regimen.

Why you need it: Nighttime is when your skin repairs itself. This breathable, lightweight formula is perfect for warmer or humid climates, providing deep hydration without heaviness. Each morning, wake up to softer, more supple skin, with visibly fewer fine lines and wrinkles.

For the best results, use alongside the full REDEFINE Regimen.

Item Number: AAPL030

Key Concerns

  • Fine Lines + Deep Wrinkles
  • Loss of Firmness
  • Pore Tightening
  • Lifting + Sculpting
  • Defining
  • Combination to Oily Skin

Skin Type: Suitable for all skin types; ideal for combination to oily skin.

Key Benefits

✔ Balances skin’s moisture overnight ✔ Visibly reduces fine lines + wrinkles ✔ Firms, lifts, and defines facial contours ✔ Promotes smoother texture and youthful glow

Powered by Advanced Ingredients

Exclusive Peptide Technology supports skin’s firmness to lift, sculpt, and minimize the appearance of wrinkles.

Retinoid Science (Retinal MD) encourages natural renewal to refine skin tone and smooth lines and wrinkles for a younger appearance.

Niacinamide (Vitamin B3) improves uneven tone, restores radiance, and supports healthy-looking barrier.

*Individual Results Will Vary.

How to Use

  1. Use nightly, in the PM, after cleansing and toning.
  2. Apply liberally and evenly over face and neck.
  3. Avoid the eye area.

Wake up looking renewed, radiant, and visibly redefined.

R+F Multi-Acid Enzyme Peel™

Experience clinical-level exfoliation from the comfort of home. This dermatologist-created resurfacing serum removes dead skin cells 5X faster* than untreated skin, revealing a smoother, more even, and radiant complexion.

Recommended Use: 3X per week, PM Size: 30 mL / 1 Fl. Oz.

Product Details

What it is: A luxurious, lightweight exfoliating serum that transforms skin overnight. It goes beyond surface-level exfoliation to diminish the look of dark spots, refine skin texture, and unveil glassy, luminous skin. Formulated for all skin types, including melanin-rich skin, it leaves the complexion feeling comfortable, polished, and visibly even-toned. Based on an ex vivo study, compared to an untreated control after 30 min. Based on an 8-week clinical and consumer study using R+F Multi-Acid Enzyme Peel three nights a week, 100% of users noticed more even-looking skin tone. Results will vary.

Why you need it: As we age, natural skin turnover slows, leading to dullness, rough texture, and enlarged pores, especially visible in deeper skin tones. This gentle yet powerful peel accelerates exfoliation, combats dullness, and fades discoloration, restoring your visibly healthy, youthful glow.

Eco-Friendly Packaging: Our bottles contain 50% post-consumer recycled material and are 100% recyclable* to support a more sustainable skincare ritual. Check local recycling guidelines.

Item Number: ENPF030

Key Concerns

  • Uneven Skin Tone + Texture
  • Dark Spots + Dullness
  • Large Pores

Skin Type: Normal, Dry, Oily, Combination (not recommended for sensitive skin)

Key Benefits

✔ Exfoliates 5X faster than untreated skin to renew skin’s surface ✔ Fades visible dark spots and discoloration ✔ Refines texture for smooth, glassy skin ✔ Reduces the look of large pores and dullness

Powered by Advanced Ingredients

ProAcid Enzyme Complex™ A dynamic blend of multi-acids (glycolic, lactic, salicylic, PHA) and papaya enzyme that gently accelerates cell renewal for a luminous, even tone.

Bakuchiol A plant-based retinol alternative that brightens skin and enhances firmness without irritation.

Niacinamide (Vitamin B3) Supports the skin barrier while improving clarity and tone.

Licorice Root Essence Calms and soothes skin for comfortable resurfacing.

How to Use

  1. Use 3X per week in the PM after cleansing and toning.
  2. Apply 2–3 pumps to the full face, avoiding the eye area.
  3. For neck and décolleté, apply an additional 2–3 pumps.
  4. Leave on, do not rinse, and follow with your usual serum and moisturizer.
  5. Always apply SPF daily in the morning while using this product.

*5x times faster than untreated skin. Individual Results Will Vary.

⚠️ Note: Not recommended for sensitive skin. Perform a patch test before first use or when combining with other active products.

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Upgrade your regimen for firmer, healthier-looking skin. Explore our science-backed skincare essentials and see the benefits for yourself.

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